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Continuing Education — "The Action Level!®"

VOLUME 10(4), April 2013
Journal of Occupational and Environmental Hygiene



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CASE STUDIES:

A Case Study and a Computational Simulation of the European Union Draft Technical Guidance Documents for Chemical Safety Assessment of Mixtures: Limitations and a Tentative Alternative
Jongwoon Kim, Sanghun Kim and Gabriele E. Schaumann

1. This article concluded that the (i)_____________ caused less
    conservative results, i.e., higher PNEC and DNEL values,
    than the (ii)_____________.

a. (i) Key Critical Method, (ii) Composite Reciprocal
          PNEC and DNEL method
b. (i) Composite Reciprocal PNEC and DNEL method,
          (ii) Key Critical Method
2. The number of components that had similar toxicity values,
    assessment factors, and weight fractions were confirmed as
    the key factors that triggered the difference between the results
    of the KCC and CR methods. _____________ can be a less
    dominant factor than the others, assuming that valid toxicity
    datasets are used for the PNEC or DNEL values.
a. The number of components that had similar
          toxicity values
b. Assessment factors
c. Weight fractions
Manikin-Based Performance Evaluation of Elastomeric Respirators against Combustion Particles
Xinjian He, Michael Yermakov, Tiina Reponen, Roy T. McKay, Kelley James and Sergey A. Grinshpun

3. The particle penetration through the faceseal leakage of a
    half-mask elastomeric respirator is generally higher than that
    through a P-100 filter of this respirator. True or False?

True
False
4. The particle penetration through a partially sealed half-mask
    elastomeric respirator is significantly affected by:
a. the challenge aerosol
b. the sealing area
c. the breathing flow rate
d. all of the above
Prediction of the Physiological Response of Humans Wearing Protective Clothing Using a Thermophysiological Human Simulator
Agnes Psikuta, Li-Chu Wang and René Rossi

5. Root-mean-square deviation (rmsd) is a typically used measure
    of goodness-of-fit in validation of physiological models. This
    parameter accounts for the quality of the experimental data
    used for a validation case. True or False?

True
False
6. The simulation of the approximate physiological human response
    in form of phases with constant power equivalent to the metabolic
    rate, and a sweat rate equivalent to the expected sweating using
    heated sweating devices is often used in practice. This approach
    is equivalent to using devices controlled by the model of human
    thermal physiology. True or False?
True
False
A Comparison of Two Sampling Methods for the Detection of Airborne Methylene Bisphenyl Diisocyanate
Joshua W. Schaeffer, Layne Marie Sargent, Delvin R. Sandfort and William J. Brazile

7. The preferred sampling method for airborne isocyanates in a fast
    reacting, two-component polyurethane system is the impinger
    method. True or False?

True
False
8. The field desorption method produced higher airborne MDI
    results during application of spray-on truck-bed liners. True
    or False?
True
False
Inflammatory Effects of Woodsmoke Exposure Among Wildland Firefighters Working at Prescribed Burns at the Savannah River Site, SC
Anna M. Hejl, Olorunfemi Adetona, David Diaz-Sanchez, Jacqueline D. Carter, Adwoa A. Commodore, Stephen L. Rathbun and Luke P. Naeher

9. Interleukin-8 can be used as a biomarker of ____________ after
    woodsmoke exposure and ambient particulates.

a. Oxidative stress
b. Acute thrombosis
c. Inflammation
d. Pulmonary disease
e. Pneumonia
10. Interleukin-8, a (an) ____________ produced by macrophages
      and other cell types such as epithelial cells, is a major mediator
      of the inflammatory response in the lung, and is also highly
      involved in the recruitment of neutrophils in the lung.
a. Chemokine
b. Protein
c. Cytokine
d. b and c
e. All of the above
Thoracic Fraction of Inhaled Fiber Aerosol
Yung Sung Cheng and Wei-Chung Su

11. The respirable particle mass (RPM) fraction is defined as
      particles that penetrate the ciliated regions. True or False?

True
False
12. The IPM is the fraction of ambient airborne particles that can
      enter the head airway, whereas the TPM refers to the portion
      of airborne particles that may penetrate the head airway.
      True or False?
True
False

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Deadline for answers is April 30, 2013.

Answers will be available online at
http://www.acgih.org/products/joeh/alanswers.htm
on May 15, 2013.

 
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