Control of worker exposure to polycyclic aromatic hydrocarbons (PAHs) is a very challenging task for the occupational health professional. PAHs comprise human carcinogens and can be absorbed by inhalation, dermally and through ingestion. Occupational exposure can be confounded by the presence of PAHs in tobacco smoke and foods. The ACGIH® Biological Exposure Indices (BEI®) Committee recommends that urinary levels of 1-hydroxypyrene be used to estimate workplace exposure to PAHs. An "Nq" designation was indicated because it was neither possible to place the determinant in the context of the current ACGIH® TLV® for PAHs mixtures nor were available data sufficiently strong to recommend a BEI® based on health effects. Therefore, the ACGIH® BEI® Committee has provided a guidance benchmark level to practitioners to indicate when occupational exposure contributes to levels of 1-hydroxypyrene to estimate occupational exposure to PAHs. The data indicate that the marker may be used to differentiate current from chronic exposure and to control for PAHs in tobacco smoke and diet. The approach proposed by the United Kingdom Health and Safety Executive is compared to the BEI®. In addition, a perspective on the use of 1-hydroxypyrene to monitor PAHs exposure is provided by a speaker from the industrial community.
This 2-½ hour webinar is presented by Glenn Talaska, MSPH, PhD., professor of Environmental Health at the University of Cincinnati School of Medicine and Vice-Chair of the ACGIH® BEI® Committee; John Cocker, PhD, Head of the Biological Monitoring Section of the Health and Safety Laboratory in the United Kingdom and also a member of the ACGIH® BEI® Committee; and Peter Boogaard, PharmD, PhD, Senior Toxicology Consultant at Royal Dutch Shell's global headquarters in The Hague (The Netherlands).
After viewing this webinar, you will gain an understanding of:
- Understand the basis for the ACGIH® PAHs BEI® using 1-hydroxypyrene
- Understand the correct sample timing and data interpretation
- Understand how to control for confounding exposures like smoking and dietary intake
- Learn how exposure in different industries affects 1-hydroxypyrene levels
- Learn the different approaches to controlling exposure of the ACGIH® BEI® Committee and the British Health and Safety Executive
- Learn to use 1-hydroxypyrene to differentiate between airborne and dermal exposure
- Learn how 1-hydroxypyrene levels can be used to determine whether exposure interventions are effective.
System Requirements:
Windows version only
Adobe Acrobat Reader 5.0 or later
Audio Speakers
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WEBINAR TEST – ACGIH® TLVs®: Practical Applications in the Workplace
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WEBINAR TEST – Biomonitoring: Development and Practical Application of Guidance Values
WEBINAR TEST – Control Banding: Uses and Misuses
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WEBINAR TEST – Derived No Effect Levels (DNELs): What Are They and How Will They Change the Occupational Health (OEL) Landscape?
WEBINAR TEST – The EH&S Professional’s Role in Emergency Response and Planning
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WEBINAR TEST – Industrial Hygienists’ Ethical Dilemmas: Basic Principles and Resolution Strategies
WEBINAR TEST – Industrial Ventilation Systems: Energy Savings and Cost Estimation
WEBINAR TEST – Managing Energy in Ventilation Systems: Variable Frequency Drives (VFDs)
WEBINAR TEST – Nanotechnology Health and Safety: Case Studies in the Occupational Setting
WEBINAR TEST – Pandemic Influenza: Minimizing Risk and Preparing for the Possibilities
WEBINAR TEST – Polycyclic Aromatic Hydrocarbons (PAHs): Controlling Exposure Using Biological Monitoring
WEBINAR TEST – Thermal Stress: Exploring Common Problems
WEBINAR TEST – TLVs® and Adjustments due to Worker Conditions
WEBINAR TEST – TLVs® and Adjustments due to Workplace Conditions
